HLH: genomics illuminates pathophysiological diversity
نویسندگان
چکیده
منابع مشابه
Comparative Genomics of the Bacterial Genus Streptococcus Illuminates Evolutionary Implications of Species Groups
Members of the genus Streptococcus within the phylum Firmicutes are among the most diverse and significant zoonotic pathogens. This genus has gone through considerable taxonomic revision due to increasing improvements of chemotaxonomic approaches, DNA hybridization and 16S rRNA gene sequencing. It is proposed to place the majority of streptococci into "species groups". However, the evolutionary...
متن کاملComplementing genomics and transcriptomics: Phosphoproteomics illuminates systems biology in prostate cancer
Integration of phosphoproteomics with traditional genomics and transcriptomics provides a more comprehensive overview of the signaling networks in advanced prostate cancer for immediate preclinical and future clinical use. Our recent publication introduces computational approaches for integrating the phosphoproteome, specifically with the intent of identifying important kinase signaling network...
متن کاملSequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins
The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here we report high-depth sequencing of 128 complete genomes of AJ controls. Compared with European samples, our AJ panel has 47% more novel variants per genome and is eightfold more effective at filtering benign variants out of AJ ...
متن کاملComparative genomics and the diversity of life
Submitted: 3 May 2016 Accepted: 11 August 2016 doi:10.1111/zsc.12211 Dunn, C. W. & Munro, C. (2016). Comparative genomics and the diversity of life. — Zoologica Scripta, 45, 5–13. In the last decade, genomics has come to play a central role in systematics and biodiversity research. In coming years, systematics and phylogenetics will come to play an increasingly important role in genomics. Here,...
متن کاملAnt genomics: strength and diversity in numbers.
A recent workshop held at the Arizona State University Center for Social Dynamics and Complexity gathered over 50 prominent researchers from around the globe to discuss the development of genomic resources for several ant species. Ants play crucial roles in many ecological niches and the sequencing of several ant genomes promises to elucidate topics ranging from the genetic basis for social com...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-05-845818